OxyContin (oxycodone hydrochloride) is an opioid drug used for the administration of moderate to severe pain, commonly for an extended time frame.
Physicians really should individualize therapy in each individual situation, applying nonopioid analgesics, prn opioids and/or combination merchandise, and Serious opioid therapy with drugs including oxycodone hydrochloride tablets inside of a progressive strategy of soreness administration which include outlined by the globe Wellbeing Firm, the Agency for Overall health Care Policy and Exploration, as well as the American Soreness Culture.
Oxycodone is existing in breast milk. Published lactation research report variable concentrations of oxycodone in breast milk with administration of speedy-release oxycodone to nursing mothers while in the early postpartum interval. The lactation scientific studies didn't evaluate breastfed infants for opportunity adverse reactions. Lactation reports haven't been conducted with prolonged–release oxycodone, which includes OXYCONTIN, and no information and facts is accessible on the results in the drug around the breastfed toddler or the effects in the drug on milk creation.
Oxycodone hydrochloride tablets are contraindicated in people with recognized hypersensitivity to oxycodone, or in any circumstance exactly where opioids are contraindicated. This involves people with important respiratory despair (in unmonitored options or perhaps the absence of resuscitative gear) and patients with acute or extreme bronchial bronchial asthma or hypercarbia.
Figure 1 demonstrates a comparison of drug liking for finely crushed OXYCONTIN when compared to powdered oxycodone HCl in subjects who obtained the two therapies. The Y-axis signifies the % of topics attaining a % reduction in drug liking for OXYCONTIN vs. oxycodone HCl powder bigger than or equal to the value on the X-axis. Somewhere around forty four% (n = twelve) had no reduction in liking with OXYCONTIN relative to oxycodone HCl.
Instruct patients to swallow OXYCONTIN tablets whole; crushing, chewing, or dissolving OXYCONTIN tablets can result in swift release and absorption of the likely lethal dose of oxycodone [see WARNINGS AND Safeguards].
OXYCONTIN check here is indicated for your administration of critical and persistent agony that needs an prolonged treatment time period with a everyday opioid analgesic and for which choice therapy alternatives are inadequate in:
Printed facts documented that elimination of oxycodone was impaired in conclusion-phase renal failure. Imply get more info elimination 50 percent-lifestyle was prolonged in uremic sufferers as a consequence of amplified quantity of distribution and lowered clearance.
Keep an eye on such sufferers for signs of sedation and respiratory depression, specially get more info when initiating therapy with OXYCONTIN.
The concomitant utilization of opioids with other drugs that have an affect on the serotonergic neurotransmitter technique has resulted in serotonin syndrome.
A study of OXYCONTIN in clients with hepatic impairment shown increased plasma concentrations than People viewed at equivalent doses here in folks with standard hepatic operate [see Medical PHARMACOLOGY].
Slicing, breaking, chewing, crushing or dissolving OXYCONTIN impairs the controlled-launch shipping and delivery mechanism and ends in the quick release and absorption of the most likely deadly dose of oxycodone.
The chance for extreme respiration issues is increased when You begin this medication and after a dose improve, or if you are taking the wrong dose/power. Taking this medication with alcohol or other drugs that could cause drowsiness or breathing issues may cause pretty severe Negative effects, which includes death. Also, other remedies can have an impact on the check here removal of oxycodone/acetaminophen from your human body, which can impact how it works.
Choose your prescribed dose each individual twelve hours at the same time each day. Usually do not acquire in excess of your prescribed dose in 12 several hours. When you overlook a dose, get your following dose at your common time.